Fat oxidation during exercise reflects a fine interplay between the cardiovascular, neurological, endocrine and muscle metabolic systems. During exercise and physical activity, the primary fuels used by muscles are carbohydrate and fat. When mild exercise is performed there is a tendency to burn relatively more fat and less glucose, but as exercise becomes more intense, a higher fraction of the energy demands of the muscle are supplied by glucose, until at the highest intensities almost only carbohydrates are used.
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