The amount of fluid in our body, which has a major influence on blood pressure, is regulated by a combination of molecules that comprise the renin-angiotensin system (RAS). The RAS is active in both the kidney and brain, but the mechanisms that control the RAS in the brain had not well defined until researchers from the University of Iowa, Iowa City, showed that in mice the RAS is active in a region of the brain known as the subfornical organ (SFO) and that RAS activity in the SFO drives increased consumption of water and salt.
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