Researchers have made a significant discovery -- the understanding of a common mechanism of cancer initiation -- that could result in better cancer assessment, prevention and detection. The researchers have discovered that certain estrogen derivatives (metabolites) can react with deoxyribonucleic acid (DNA) to cause damage that may initiate a series of events leading to breast, prostate and other cancers. They found evidence in a simple urine test in humans. Estrogens can initiate cancer when natural mechanisms of protection do not work properly in the body, allowing estrogen metabolites to react with DNA.
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