A new class of synthetic estrogens could offer women most of the benefit and less of the risk of standard hormone replacement therapy, a study in animals suggests. Mice with induced Alzheimer's-like symptoms got better when given the synthetic hormone propylpyrazole triol (PPT). "It improved behavior much the way that estrogen does," said one of the researchers. But unlike estrogen, which enlarges the uterus and is a known risk factor for endometrial and breast cancer, PPT caused no obvious changes to the animals' reproductive tract.
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