ORIGINAL ARTICLE: Rituximab and Intravenous Immune Globulin for Desensitization durin

New cases in Pous 2064, HIV = 175, AIDS = 26, Death = 2. HIV rate is very high in Housewives than sex workers in Nepal ! ! ! HIV status in Nepal till 2005: Total Adult=70000, Adult Prevalence (15-49)=0.55%, Number of Women (15-49) LWHA=15,310 (22%), HIV Prevalence rate in IDUs=32.7%, HIV prevalence rate in sex worker=3.8%, HIV prevalence rate in client of SW=2.1%. The latest U.N. report shows that 65 million people have been infected with HIV since it was first identified 25 years ago. Twenty five million people have died of AIDS.

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ORIGINAL ARTICLE: Rituximab and Intravenous Immune Globulin for Desensitization durin

NEJM The New England Journal of Medicine

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ORIGINAL ARTICLE: Rituximab and Intravenous Immune Globulin for Desensitization durin - 16-07-2008, 02:30 PM

This open-label, phase 1-2, single-center study examined the use of intravenous immune globulin and rituximab to reduce anti-HLA antibodies and improve transplantation rates in 20 highly sensitized patients. Sixteen patients (80%) subsequently received a transplant, and the 1-year survival rates for patients and allografts were 100% and 94%, respectively. Larger and longer trials are needed to assess the safety of this approach.

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