ORIGINAL ARTICLE: Brief Report: Effect of Gene Therapy on Visual Function in Leber's

New cases in Pous 2064, HIV = 175, AIDS = 26, Death = 2. HIV rate is very high in Housewives than sex workers in Nepal ! ! ! HIV status in Nepal till 2005: Total Adult=70000, Adult Prevalence (15-49)=0.55%, Number of Women (15-49) LWHA=15,310 (22%), HIV Prevalence rate in IDUs=32.7%, HIV prevalence rate in sex worker=3.8%, HIV prevalence rate in client of SW=2.1%. The latest U.N. report shows that 65 million people have been infected with HIV since it was first identified 25 years ago. Twenty five million people have died of AIDS.

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ORIGINAL ARTICLE: Brief Report: Effect of Gene Therapy on Visual Function in Leber's

NEJM The New England Journal of Medicine

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ORIGINAL ARTICLE: Brief Report: Effect of Gene Therapy on Visual Function in Leber's - 21-05-2008, 03:02 PM

A form of Leber's congenital amaurosis is caused by mutant RPE65, a critical component of the visual cycle. Two early clinical trials to assess subretinal injection of a viral vector containing RPE65 in young adults with advanced retinal degeneration show that this approach is generally safe in the short term, although one group reported an adverse event: macular hole. The authors observed improvement in some measures of visual function.

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