ORIGINAL ARTICLE: DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer

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ORIGINAL ARTICLE: DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer

NEJM The New England Journal of Medicine

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ORIGINAL ARTICLE: DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer - 12-03-2008, 03:40 PM

Methylation of the promoter region of a gene is a mechanism that influences gene expression. In this study of patients with stage I non-small-cell lung cancer (NSCLC), methylation of seven genes -- p16, CDH13, APC, RASSF1A, MGMT, ASC, and DAPK -- from tumor and lymph-node specimens was studied. Four genes (p16, CDH13, RASSF1A, and APC), when methylated, were associated with recurrence after surgery with curative intent.

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