Single-nucleotide polymorphisms (SNPs) in chromosomal regions 8q and 17q are associated with susceptibility to prostate cancer, although each SNP has only a modest association with the disease. This study identified five SNPs in these chromosomal regions that had a strong association with prostate cancer when combined. The strength of the association increased with the number of prostate-cancer-associated SNPs in the genome. The addition of a positive family history gave an even greater association. This study shows how weak associations between genetic variants and a disease that have been found in genomewide association studies can be strengthened through combinatorial analysis.
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