Facts on Diabetes

[SUMAN-SAJAN]

# 3 out of 4 diabetic die of vascular complications
#people with diabetes have 4 fold high risk of dying from cardiovascular diseases.
#88% young diabetic have sign of carotid atherosclerosis on USG
#Antiplatelet therapy is simple intervention to reduce cv complications
#in elderly subjects diabetic is a factor in =
-cognitive decline
-depression
-urinary incontinence
#New diagonostic criteria in diabetes : fasting glucose >7 mmol/l on 2 readings at more than 3 weeks interval.

# 3 frequent complications of diabetes:
-trophic disorders of feet
-metabolic decompensation
-hypoglycaemia following antidiabetic therapy

# New antidiabetics
-glucokinase activators GKA
-glycogen phosphorylase inhibitor GPI
-fructose 1,6- bis phosphatase inhibitor

# New insight in Islet transplantation
Porcine islets xenotransplantation may prove to be a promising factor in reversing type I diabetes , says research of Emory transplant center, Canada.

-suman

[SUMAN-SAJAN]

Alcohol and diabetes

Moderate consumption: decrease insulin resistance {protective cvs effects**
low or high intake : increase insulin resistance

Alcohol can cause both hypo and hyperglycaemic effects in diabetic.
moderate consumption: increase glucose stimulated insulin secretion
decrease gluconeogenesis in liver
increase insulin sensitivity

result-decrease blood insulin

heavy consumption:increase peripheral resistance
decrease insulin sensitivity
decrease glucose oxidation

result : diabetogenic , increase blood glucose

Effect of alcohol on diabetic complications

#Refractory hypertension
#Exacerbate neuropathic symptoms
#Erectile dysfunction
#Complicated retinopathy
#Increase risk of premature mortality

-suman

[SUMAN-SAJAN]

Antioxidants and Diabetes

1 Adequate amount of Vitamin A,C,D,E are required for normal intestinal function and these vitamins help reduce the oxidative stress in Diabetes.

2 Vit.E preserve endothelial function and reduce vascular complications and inhibit development of atherosclerosis.

3 Vit.C reduce the monocyte adhesion to endothelial cells and inhibit LDL oxidation and decreases Nitric oxide oxidation, thus improve vasodilatation.

4 Vit. D affect vascular remodelling.

Thus combining the existing therapeutic agents with antioxidants complement the mechanism of decreasing oxidative stress.

[SUMAN-SAJAN]

Obesity and Type I diabetes

According to a research at Wake Forest University School of Medicine ,obesity may accelerate onset of the Type I Diabetes in some patients.

But it was observed only in some patients with compromised pancreatic function.

As the birth weight decreases , the age at which Type I Diabetes appears is delayed.

[SPRimal]

thanks for sharing the knowledge!

[de.malady]

very nice info frnds..
what about the iv -insulin- therapy & also the hot -insulin inhalers- that i heard are out in the market; if any1 knows please mention.. thanks