Coffee-Gene Interaction Raises Heart Attack Risk

[Angel]

A new study shows people with a genetic variation who drink more coffee are more likely to have a heart attack.

An enzyme called cytochrome P450 1A2 (CYP1A2) metabolizes caffeine in the liver. Variations of the gene for this enzyme can slow or quicken caffeine metabolism.

Researchers at the University of Toronto wanted to find out whether gene variations of CYP1A2 change the association between drinking coffee and the risk of nonfatal heart attack. They studied 2,014 patients with a first nonfatal heart attack and 2,014 healthy people.

For study participants with the slow variation of the gene who drank two to three cups of coffee a day there was a 36-percent increased risk of having a heart attack. Those who drank four or more cups had a 64-percent increased risk. Study participants with the rapid gene variation who had the same amount of coffee reduced their odds of a heart attack by 22 percent and 1-percent respectively.

"In summary, consistent with most case-control studies, we found that increased coffee intake is associated with an increased risk of nonfatal MI (myocardial infarction or heart attack)," study authors say. "The association between coffee and MI was found only among individuals with the slow CYP1A2*1F allele, which impairs caffeine metabolism, suggesting that caffeine plays a role in the association."

[bishnurath]

it was a new info
normally caffein stimulates the brain but habitual use of caffein leads to addiction nd ones mind is relatively dull when not having coffee.
coffee also worsens insomnia.
added to it the risk of heart attack
so i think its better to rethink if u r a habitual coffee drinker