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| | Journal Club Take part in the discussion of an article published in the various Medical Journal, Journal club info and more... | MMSN Journal Club at KMC on Jan 24, 2006
Published by Angel
15-01-2006
| | MMSN Journal Club at KMC on Jan 24, 2006
MMSN Journal Club Topic: Efficacy of Low-dose Acetazolamide (125 mg BID) for the Prophylaxis of Acute Mountain Sickness: A Prospective, Double-blind, Randomized, Placebo-controlled Trial - BUDDHA BASNYAT1, JEFFREY H. GERTSCH 2, E. WILLIAM JOHNSON 2, FRANCO CASTRO-MARIN 2, YOSHIO INOUE 2, and CLEMENT YEH 2
Speaker: Mr. Suvash Shrestha, MBBS 7th Batch, KMC Place: Lecture Hall B, Academic Building, KMC, Sinamangal Date: Jan 24, 2006 Time: 5.00 PM (sharp) All the interested medical students, interns, doctors and individuals are invited in the Journal Club. N.B. Please download the article to read its contents from the attachment. | | | | |
By
Mati
on
16-01-2006, 03:14 AM
| | Great Dr Angel: Keep it up!
Well friends,
It is a matter of pride indeed to see that KMC is going to organizing for the second time.
Good ***, guys. I really appreciate your's commitment and zeal to work in the field of academic medicine. Mountain Medicine Society of Nepal is the medium for that. It seems, it has really worked well.
This time, the article is really megadose one. This is an article about the research on the doses of Diamox that prevents AMS if taken one day prior ascent BD in 250mg but the study is fantastic to come out with lower doses. Prof Buddha was involved in the study and he will be there. Don't forget to delve into the STUDY Design of the research. It has much to do with this study. It is very rigorously carried our RCT.
The abstract of the study goes: Quote:
The objective of this study was to determine the efficacy of low-dose acetazolamide (125 mg twice daily) for the prevention of acute mountain sickness (AMS).
The design was a prospective, double-blind, randomized, placebo-controlled trial in the Mt. Everest region of Nepal between Pheriche (4243 m), the study enrollment site, and Lobuje (4937 m), the study endpoint.
The participants were 197 healthy male and female trekkers of diverse background, and they were evaluated with the Lake Louise Acute Mountain Sickness Scoring System and pulse oximetry.
The main outcome measures were incidence and severity of AMS as judged by the Lake Louise Questionnaire score at Lobuje. Of the 197 participants enrolled, 155 returned their data sheets at Lobuje.
In the treatment group there was a statistically significant reduction in incidence of AMS (placebo group, 24.7%, 20 out of 81 subjects; acetazolamide group, 12.2%, 9 out of 74 subjects). Prophylaxis with acetazolamide conferred a 50.6% relative risk reduction, and the number needed to treat in order to prevent one instance of AMS was 8. Of those with AMS, 30% in the placebo group (6 of 20) versus 0% in the acetazolamide group (0 of 9) experienced a more severe degree of AMS as defined by a Lake Louise Questionnaire score of 5 or greater (p = 0.14).
Secondary outcome measures associated with statistically significant findings favoring the treatment group included decrease in headache and a greater increase in final oxygen saturation at Lobuje. We concluded that acetazolamide 125 mg twice daily was effective in decreasing the incidence of AMS in this Himalayan trekking population.
| Have a nice discussion out there,
best wishes,
mati
from: Ilam Hospital, Ilam | | |
By
Ajay
on
19-01-2006, 06:00 PM
| | its gr8 news. we ll spare no pain to make it a mega success. all the best for suvash. | | | | | | achamma hai nepal ma teti dherai himal haru chha tara kuire haru matra expert dhanna mmsn le laaj bachayeko chha long live mmsn | | |
By
medic
on
20-01-2006, 06:05 AM
|  all the best!!!!
all the best Suvash !!! | | |
By
JNUS
on
23-01-2006, 11:13 PM
| | Best of luck to Suvash Shrestha, for his today evening 's presentation..
do ur best. | | |
By
Angel
on
24-01-2006, 09:42 AM
| | MMSN Journal Club was a great success
Today's MMSN Journal Club at KMC was a great success. Dr. Prajan, Dr. Devis, Dr. Sanju, Dr. Soni, Medical Student from IOM, KMC and doctors from KMC were present.
Ms. Sarensa Palikhe 7batch talked about AMS and Mr. Suvash Shrestha 7th batch talked about the article. | | |
By
Mati
on
25-01-2006, 03:04 AM
| | That is excellent!
Dear Dr Angel, Quote:
Today's MMSN Journal Club at KMC was a great success. Dr. Prajan, Dr. Devis, Dr. Sanju, Dr. Soni, Medical Student from IOM, KMC and doctors from KMC were present.
Ms. Sarensa Palikhe 7batch talked about AMS and Mr. Suvash Shrestha 7th batch talked about the article.
| Congrats for organizing this MMSN Journal Club amidst such an uncertainty and odds!
You deserve all the kudos,
Good job, Suvash and Sarensa!~
Welldone!
I am waiting to read your experience here in the forum.
best wishes,
mati
from: Ilam hospital, Ilam | | |
By
Suvash
on
27-01-2006, 12:04 AM
| | hi
hello everybody,
i thank you all for your wishes...
and for me it will remain an unforgottable evening...sarensa and i both were somehow prepared for the journal club..we had informed all our seniors and even put on a notice about the occasion with our names in big letters..ha ha  so that the readers donot miss our names...
anyway we were ready and then we got a message that prof. basnet won't be able to make it to the journal club today...it was little disappointing for us, esp me because the article i was going to present was the study done by basnet sir, so i was expecting him and what a presentation it would have been to discuss about his own research...right infront of him...
anyway we were ready and we managed the lecture halll B...for the pupose..
and we were expecting-if not basnet sir- other members- Dr prajan,dr debesh dr soni, dr anupa, dr anil and others.. however prajan dai, debesh dai, and soni didi did not disappoint us and they made the journal club deserve the applause that it got later...
and we were ready, it waas 3:55, sarensa was fixing the projector and to our utter disappointment, the power went off...it was an loadshedding day - 4 to 6 pm....we were helpless, we could do nothing without electricity, it was like adding insult to injury...we were frustrated and were almost sure that the journal club will be postponed but there was- as ususal- our saviour- angel dai, though he could not bring the lights but he definitely made the program possible...he was the man behind the screen...
angel dai thank you so much..
and at about 5  m despite all the adverse circumstances, the program kicked off, we had no light and no powerpoint but still we did it, it was like a classical class with out any modern utilities...
there were as many as 30 participants...they all attended the presentaiton with much interest and curiosity.. personally speaking it was one of the best experiences in my medical life....there was lots of interaction and i am sure everyone enjoyed..
in a way we proved if we are determined to do something nothing can stop us...because despite no lights, no powerpoint and getting late in the evenong, we did it.... | | |
By
Mati
on
27-01-2006, 03:52 AM
| | Great Suvash,
Congrats!
Nice memo right here.
Keep it up.
Where is Sarensa?
Could you write something about that MMSN JC?
I waiting to read like Suvash's.
best wishes,
mati
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