Heights and haematology: the story of haemoglobin at altitude

There is much much query, study and researches in the past from as early as 1950s. There is one review published recently in Postgraduate Medical Journal

Journal:

The gist:

In order to compensate for the low partial pressure of oxygen at altitude, the human body undergoes a number of physiological changes. A vital component in this process is the increase in the concentration of circulating haemoglobin. The role of HIF-1{alpha**, erythropoietin and red blood cells in this acclimatisation process is described, together with the fall in plasma volume that increases the concentration of haemoglobin in the early stages of hypoxic exposure.

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mati