Uses based on scientific evidence (Grade* )

[Adrenaline]

Vitamin A deficiency may occur after chronic lack of adequate amounts of vitamin A or beta-carotene. Vitamin A is necessary for vision, and an early sign of vitamin A deficiency is keratomalacia (night blindness). Prolonged deficiency may lead to xerophthalmia (dry eye). Eventually, blindness can occur due to damage to the retina and cornea. Vitamin A is necessary for healthy growth and development, and recommended daily amounts (RDA) should be assured, particularly in children.
Acne ( grade A)

Derivatives of vitamin A, retinoids, are used to treat skin disorders such as acne. Topical and oral prescription medications, such as tretinoin (Avita?, Renova?, Retina-A?, Retin-A Micro?) and isotretinoin (Accutane?), are available for treatment. Isotretinoin may cause severe side effects and should be used only for severe resistant acne. Isotretinoin must not be used in women who are pregnant, plan to become pregnant, or have a chance of being pregnant due to a risk of severe birth defects. These medications should be prescribed and coordinated by a qualified licensed healthcare professional. Vitamin A supplements should not be used simultaneously due to a risk of increased toxicity.
Acute promyelocytic leukemia (All-trans retinoic acid) ( grade A)

The prescription drug All- Trans -Retinoic Acid (ATRA, Vesanoid?) is a vitamin A derivative which is an established treatment for acute promyelocytic leukemia and improves median survival in this disease. Treatment should be under strict medical supervision. Vitamin A supplements should not be used simultaneously with ATRA due to a risk of increased toxicity.
Measles (supportive agent) ( grade A)

Vitamin A should be administered to children diagnosed with measles in areas where vitamin A deficiency may be present. Measles is a viral disease that can lead to serious complications such as diarrhea, pneumonia, and encephalitis. Supplementation with vitamin A in children with measles has been shown to be beneficial, by decreasing the length and impact of the disease. Side effects such as diarrhea, pneumonia, and death have been reduced with the use of vitamin A. Management of measles should be under strict medical supervision.
Xerophthalmia (dry eye) ( grade A)

Oral vitamin A is the treatment of choice for xerophthalmia due to prolonged vitamin A deficiency, and should be given immediately once the disorder is established.
Malaria (supportive agent) ( grade A)

Limited research suggests that vitamin A may reduce fever, morbidity, and parasite blood levels in patients with malaria ( Plasmodium falciparum infection). However, there is no evidence that vitamin A is equivalent or superior to well-established drug therapies used for prevention or treatment of malaria. Patients with malaria or living/traveling in endemic areas should speak with a physician about appropriate measures.
Retinitis pigmentosa ( grade B)

Retinitis pigmentosa is a genetic disorder that affects night vision. Early symptoms include night blindness and progressive loss of vision over time. Based on recent findings, 15,000 IU daily of vitamin A in the palmitate form has been recommended in patients with retinitis pigmentosa.
Antioxidant ( grade B)

The benefits to humans of potential antioxidant activity are not clear.
Breast cancer ( grade C)

Research results are not clear as to whether vitamin A is beneficial in the treatment or prevention of breast cancer. Patients receiving chemotherapy or radiation therapy for cancer should speak with their doctor(s) before taking antioxidants such as vitamin A during treatment, due to possible interference.
Cataract prevention ( grade C)

Vitamin A has been suggested to prevent cataract formation. Carotenoids such as beta-carotene, lutein, and zeaxanthin may decrease the risk of severe cataracts. There is not sufficient evidence to form a clear conclusion at this time.
Diarrhea ( grade C)

Vitamin A may reduce the severity and duration of diarrheal episodes in malnourished children but not in well-nourished children. Since diarrhea is a major cause of morbidity and mortality in developing countries, vitamin A supplementation may be considered in undernourished children with diarrhea.
HIV Infection ( grade C)

The role of vitamin A in the prevention, transmission, or treatment of HIV is controversial and not well established. A clear conclusion cannot be formed based on the available scientific research.
Immune function ( grade C)

Vitamin A deficiency may compromise immunity, but there is no clear evidence that additional vitamin A supplementation is beneficial for immune function in patients who are not vitamin A deficient.
Infant mortality ( grade C)

There is a limited amount of research in this area, with mixed results. Some evidence suggests possible decreases in infant mortality with vitamin A supplementation, while other research reports no benefits. A clear conclusion cannot be formed based on the available scientific research.
Iron deficiency anemia (grade C)

Vitamin A supplementation in combination with iron may have beneficial effects in patients with iron deficiency anemia, including children and pregnant women. It is not clear that there are benefits in individuals who are not vitamin A deficient. This area remains controversial, and further evidence is necessary before a clear conclusion can be drawn.
Photoreactive keratectomy (grade C)

Photoreactive keratectomy is a type of laser eye surgery used to correct nearsightedness. High-dose vitamin A supplementation (50,000 to 75,000 units) in addition to vitamin E (230mg) has been suggested to help improve ocular healing after surgery and to improve visual acuity, although additional evidence is necessary before a definitive conclusion can be reached.
Polyp prevention (grade C)

Alpha-carotene and vitamin A may protect against recurrence of polyps and adenoma in nonsmokers and nondrinkers or be indicative of compliance or another healthy lifestyle factor that reduces risk. Further research is needed before a conclusion can be drawn C
Pregnancy-related complications (grade c)

Maternal vitamin A deficiency is common in developing countries. Beta-carotene may reduce pregnancy-related complications and mortality in such individuals. However, excess intake of vitamin A has been reported to increase the risks of some birth defects. Vitamin A supplementation above the RDA is therefore not recommended in pregnancy.
Skin cancer prevention (grade C)

It is not clear if vitamin A or beta-carotene, taken by mouth or used on the skin with sunscreen, is beneficial in the prevention or treatment of skin cancers.
Weight loss (grade C)

Daily vitamin A with calcium has been suggested for weight loss, and in one study an average loss of 2 pounds was reported after two years of supplementation in young women.
Wound healing (gradeC)

In preliminary study, retinol palmitate significantly reduced rectal symptoms of radiation proctopathy, perhaps because of wound-healing effects. Further research is needed to confirm these results.
Lung cancer (gradeC)

Vitamin A has been studied as a possible treatment for lung cancer, without evidence of benefits. Available evidence suggests that high-dose Vitamin A and beta-carotene may actually increase the risk of adverse effects, especially among alcohol users and smokers.
Chemotherapy adverse effects (grade D)

Vitamin A supplementation does not appear to improve chemotherapy-related side effects including nausea, vomiting, diarrhea, or mouth sores.