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Protein related to formation of epithelial cell junctional complexes containing zona
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Protein related to formation of epithelial cell junctional complexes containing zona -
17-09-2006, 08:31 AM
A deficiency of the following proteins would most likely prevent formation of epithelial cell junctional complexes containing zona occludens, zona adherens, and desmosomes?
A. Connexin
B. Desmoglein
C. E-cadherin
D. Keratin
E. Occludin
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Thats right dr_ravi, the correct answer is C. The formation of the junctional complex relies on the homotypic interaction between E-cadherin proteins on adjacent cells. This interaction initiates the formation of the zona adherens, including signaling pathways, that are then activated to initiate the formation of the zona occludens and desmosomes.
Connexins (choice A) form gap junctions, which are not part of a junctional complex.
Desmoglein (choice B) is a cadherin specific to desmosomes; lack of this protein would affect only desmosome formation.
Intracellular keratin intermediate filaments (tonofilaments) (choice D) connect the desmosomes in epidermal cells; lack of this protein would not affect the entire junctional complex.
Occludin (choice E) is one of the transmembrane protein linkers that form the tight junction of the zona occludens; lack of this protein would not affect the other elements of the junctional complex.
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