The most powerful chemotactic effect on neutrophils

[Oak]

A 8 year old girl is walking across a vacant lot and steps on a nail. The next day, her foot is sore and the wound appears inflamed. During these early stages of infection, which of the following compounds exert the most powerful chemotactic effect on neutrophils, causing them to migrate into the inflamed area?

A. C5a and IL-8
B. IL-1 and tumor necrosis factor
C. LTC4 and LTD4
D. PGI2 and PGD2
E. Thromboxane and platelet activating factor

[Hero]

C5a, IL-8, Leukotriene B4 and Bacterial products are the most important substances mediating the processes of chemotaxis. So I go for (A) C5a and Il-8.

[bharat]

i will go for hero that is also what i learned as far iam concerned

[Oak]

Thats right The correct answer is A. The most important chemotactic factors for neutrophils are the complement factor C5a and the interleukin IL-8.

The cytokines IL-1 and tumor necrosis factor (choice B) have complex, similar actions, including stimulation of production of many acute-phase reactions, stimulation of fibroblasts, and stimulation of endothelium.

Leukotrienes LTC4 and LTD4 (choice C) cause increased vascular permeability.

Prostaglandins PGI2 and PGD2 (choice D) mediate vasodilation and pain.
Thromboxane and platelet activating factor (choice E) induce platelet changes

[Hero]

Good explanation. Here is one chart I am attaching in this post, look at this.

[bharat]

thanks hero it will be usefull for quick review

[phenobarb]

Thanks Hero,,,This chart is really helpful. Looking at this chart I got lots of idea. Many thanks

[Hero]

Originally Posted by bharat

thanks hero it will be usefull for quick review

thanks to u also bharat

Originally Posted by phenobarb

Thanks Hero,,,This chart is really helpful. Looking at this chart I got lots of idea. Many thanks

my pleasure