| Re: hello i need answer -
24-03-2007, 08:08 PM
As with all lipid soluble anaesthetic drugs, the short duration of action of SodiumThioPental is almost entirely due to its redistribution away from central circulation towards muscle and fat tissue.
Barbiturates have anesthetic, sedative, and hypnotic properties but Barbiturates do not have analgesic effects.
Thiopental is an ultra-short acting barbiturate and is most commonly used in the induction phase of general anesthesia. Following intravenous injection the drug rapidly reaches the brain and causes unconsciousness within 30–45 seconds. At one minute, the drug attains a peak concentration of about 60% of the total dose in the brain. Thereafter, the drug distributes to the rest of the body and in about 5–10 minutes the concentration is low enough in the brain such that consciousness returns. Thats the reason@#@# | 
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