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| | Clincal Science Tips and tricks to survive in the Clinical Science, share your clinical rotaion and lot more | | New Member | | Posts: 15 Thanks: 0
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Join Date: Nov 2005 Location: Kathmandu | | | Gastric Irritation by NSAIDs -
14-03-2006, 12:01 AM
[color="Blue"]We all know NSAIDs cause gastric irritation and they are also the main culprit for having gastric ulcers. Do they also cause gastric irritation if given Intramuscular?if yes/no, how(mechanism of action)?[/COLOR] | | The Following User Says Thank You to Dev For This Useful Post: | |  | Senior Member | | Posts: 627 Thanks: 8
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Join Date: Oct 2005 | | |
14-03-2006, 09:01 AM
Most NSAIDs act as non-selective inhibitors of the enzyme cyclooxygenase, inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. Cyclooxygenase catalyses the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation. This mechanism of action was elucidated by John Vane, who later received a Nobel Prize for his work.
I think the MOA for gastric irritation for IM is as same as that of oral but its less however in high dose it might does the same. I am not quite sure about it.
Although, selective COX2 inhibitor has also been introduced. | | The Following User Says Thank You to Pal For This Useful Post: | |  | xenoMED Advisor | | Posts: 598 Thanks: 4
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Join Date: Oct 2005 Location: Balkumari, Lalitpur. Nomore in ER/Hosp. | | |
18-03-2006, 06:22 AM
Yes, gastric irritation occurs in both types. i think bioavailabilty of IM > oral so it has to be more in IM NSAIDs but i am not quite sure about it. i ll try to bring down more if i can.
remember that silence is sometimes the best answer | | The Following User Says Thank You to JNUS For This Useful Post: | | | Thread Tools | Search this Thread | | | | | Display Modes |  Linear Mode | 
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