Diabetic nephropathy is one of the causes of Chronic Renal Failure, when the glomerular filteration rate (G. F. R.) falls below a certain limit. The excretion of urea depends on the G. F. R., when this drops to about 30% of normal, retention of urea occurs. The raised concentration of urea in the plasma increases the concentration of urea in the filtered fraction and by this an adequate excretion is maintained. In addition to urea, sulphate and phosphate are retained together with potential toxic substances. -
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Creatinine is a waste product that is normally filtered from the blood and excreted with the urine. When kidneys start to fail, creatinine builds up in the blood. -
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Approximately 20% to 30% of all diabetics will develop evidence of nephropathy, although a higher percentage of type I patients progresses to ESRD. -
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