| [RESEARCH] Plant based insect repellent and insecticide treated bed nets to protect a -
16-10-2007, 07:20 PM
Objective To determine the effectiveness in reducing malaria of combining an insect repellent with insecticide treated bed nets compared with the nets alone in an area where vector mosquitoes feed in the early evening.
Design A double blind, placebo controlled cluster-randomised clinical study.
Setting Rural villages and peri-urban districts in the Bolivian Amazon.
Participants 4008 individuals in 860 households.
Interventions All individuals slept under treated nets; one group also used a plant based insect repellent each evening, a second group used placebo.
Main outcome measure Episodes of Plasmodium falciparum or P vivax malaria confirmed by rapid diagnostic test or blood slide, respectively.
Results We analysed 15 174 person months at risk and found a highly significant 80% reduction in episodes of P vivax in the group that used treated nets and repellent (incidence rate ratio 0.20, 95% confidence interval 0.11 to 0.38, P | 
Linear Mode
