Coronary heart disease, risky for women why???

[reg_an]

hello....
can anyone make me clear that ,"why there is more risk of having coronary heart diseases in female than in male suffering from diabetes mellitus?"

[Rajiv]

Women have more risk only after Menopause ( so far as I know). The fact is different changes occur after Menopause.Like 'Estrogen' protects blood vessels prior to menopause. In post-menopausal women, the wall of blood vessel changes and shows high afinity to plaque and clot formation. Moreover fibrinogen level in blood is higher.
Many drugs which are used for heart disease in men show side effects and low or high effect in women. eg coagulation inhibitors like Heparin can lead to severe bleeding.

[reg_an]

what is the relation of having diabetes mellitus?thanxs for explaining abt the role of estrogen hormone produced during the reproductive age group of female......but how it plays role in diabets millitus patients?

[Rajiv]

what is the relation of having diabetes mellitus?

Diabetes mellitus accompanied mostly by Highblood pressure injures blood vessels. In this case it is not only coronary arteries which is damaged, it can be arteries in Brain, kidney or elsewhere.

Biochemistry:
Insulin---> promotes Lipid synthesis
High Blood sugar level----> Inhibits Insulin synthesis / Insulin Resistence
Low Insulin/Insulin resistence----> Free Fatty acid in Blood---->LDL/Hypertonus--->Plaque