Rather, it was quoted as : "Please note that due to safety reasons this trial was terminated on the 8th September 2005."
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1. What was the safety reason for which this study was prematurely terminated (though not mentioned in the original paper)? Please read following link: ISRCTN75784880 - An open randomised comparison of Gatifloxacin versus Cefixime for the treatment of uncomplicated enteric fever
As the article clearly states the trial was stopped because gati was found to be so effective in comparison to cefxime that the data safety monitoring board thought it was unethical to continue the trial based on priori defined numbers. This was not for safety reasons.
Originally Posted by Anilpandit - Trails are stopped early due to various reasons. One being if a drug is found to be very very effective than other compared drug. Then the trial is stopped in the middle because the difference in out come was so huge that you dont' need to reach the target sample size to have statistically significant results.
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I hope the trial registration done by Dr Jeremy Farrar, Funded by The Wellcome Trust (UK) (grant ref: 061330), and Sponsored by University of Oxford (UK), is same with the study done by Dr Pandit. Finally making me confused regarding completion of study ? and no of target trials and study population ; termination of the trial ?
What was the trial Period ? Date of starting to end , Please !
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The drug company pulled the drug out in the USA whilst the trial was going on
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Can we use the medicine for study / practice that has not approved for therapeutic use in nepal, or is it approved in Nepal?
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Nepal Pharmacy Council - If your concern is for GatiIfloxacin than I want to inform you that this drug not yet approved for therapeutic use in Nepal.
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To : Dr. Pandit
I don't know why but i am eager to know whether this particular study is the Primary interest of the 1st author (Dr. Pandit) or the interest of Funding and Sponsoring Org. or interest of non-nepalese Foreign doctor involved in this study ?
I think you are too far now to treat nepalese population but what is the final effect of your study in Patan Hospital and You ???
Are Doctors Prescribing GatiIfloxacin in Patan for Typhoid Fever ?
Are you Prescribing GatiIfloxacin in Maryland , even for a single case of Typhoid Fever there ? If Not, are you ready to prescribe it for non-diabetic american out there ?
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Being the first author of the article, I would end my discussion saying that I would take gatifloxacin if I get typhoid. I would treat my brothers, father and mother with gatifloxacin if they get typhoid and don't have diabetes.
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To my little knowledge Study should be based on ethics, should be harmless to patient, should be aimed to result in benifit to medicine and also are pillars of it.
I am so much excited to know the application of the study for the benifit of mankind in Medicine ....?? What is being done and happening after this study?
Are we all ready to use it ?
Are we getting approval of it or already got one ?
Final Question being a young practicionar , Shall we start prescribing it or still long way to go ?