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Originally Posted by Graduate 06 In case of -Renal Artery Stenosis-, ACEI may aggravate already deteriorated ranal function. |
This is true, but what is the mechanism? I have already highlighted the exact mechanism. Actually in renal artery stenosis, efferent arteriole constriction by angiotensin II maintains the glomerular filtration and ACE-I inbihits the conversion of AI to AII and thus glomerular filtration is reduced --renal failure occurs. That's why ACE-I is usually not used in renal artery stenosis.
But ACE-I is drug of choice in diabetic nephropathy. Why?