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Originally Posted by Oak AII, however, preferentially vasoconstricts the efferent arteriole in the nephron, maintaining a reasonable glomerular filtration rate even with the reduced renal plasma flow. Captopril (an angiotensin-converting enzyme inhibitor) inhibits the conversion of angiotensin I to AII. The captopril-mediated decrease of AII will actually decrease glomerular filtration in the kidney with renal artery stenosis, because decreasing efferent constriction causes the glomerular capillary pressure to fall. |
I was curious to know why ACE-I are contraidicated in renal artery stenosis, this explanation solved my question. Tnx