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Originally Posted by bharat  A 20 -year old male present in the emergency department with a lymphoma involving the mediastinum that is producing respiratory distress.
The lymphocytes are most likely to have cell surface markers characterstic of which of the following.? 
A. B Lymphocyte.
b. T Lymphocyte.
c. Macrophage.
d. Dendritic reticulum cells.
e. Langgerhans cell. |
bharat I would go for
A, I think its
Primary Mediastinal B-cell lymphoma.
Primary mediastinal B-cell lymphoma (PMBL) is a diffuse large B-cell lymphoma that arises in the thymus and mainly affects young adults.
PMBL was recognized as a specific entity in the Revised European-American Classification of Lymphoid Neoplasms (REAL) and accounts for approximately 5% of all patients with aggressive lymphomas, a frequency roughly similar to that of Burkitt disease and lymphoblastic lymphoma.
New evidence suggests that this disease may resemble Hodgkin disease more so than other types of large B-cell lymphoma. Because of its skewed age distribution, PMBL accounts for a much higher proportion of both younger patients and those undergoing autologous transplantation. Fifty to eighty percent of patients are cured with a modern intensive combination chemotherapy that is often followed by involved field radiation or autologous transplantation.